Newborn Screening Panel
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| WSLH Department: | Newborn Screening Laboratory |
| WSLH Test Code: | NB28100 |
| Day(s) Performed: | Monday - Saturday |
| Turn-around Time: | 48-72 hours for screening negative (normal) results. Screening positive (abnormal) results are communicated to health care provider as soon as they are available. |
| Recommended Uses: | Screen babies for listed congenital disorders. See “Includes” under Test Method tab. |
| Pre-approval: | Not necessary |
| Contraindications: | This panel is a screening test and is not to be interpreted as diagnostic testing. Testing reference ranges and included interpretations may not be suitable for patients less than 24 hours of age at collection. |
| Additional Tests Performed: |
| Preparation for Collection: | See back of collection card (213), and guidance on the newborn screening website. |
| Specimen Requirements: | Whole blood spotted on filter paper. The filter paper is part of the collection kit. |
| Collection Instructions: | Specimens should be collected within 24-48 hours after birth. For extended hospitalizations, follow the recommendations posted on the newborn screening website. |
| Collection Kit/Container: |
213-Newborn Screening Blood Collection Card |
| Requisition Form: |
Attached to blood collection card |
| Required Information: | Each data field on the requisition form |
| Rejection Criteria: | Newborn screening specimens are deemed unsatisfactory for testing for the following reasons: Blood clots; Layered blood; Incomplete saturation; Plasma separation for red blood cells; Contamination of filter paper; Damage to filter paper; Blood on tan cover; Delay in transit more than seven days; Insufficient sample quantity. |
| Specimen Handling: | Dry card horizontally for a minimum of 3 hrs. Dried specimens should be transported to State Laboratory of Hygiene within 24 hours of specimen collection (the State Laboratory of Hygiene provides a next-day courier delivery service). |
| Packaging Requirements: | Dry card horizontally for a minimum of 3 hrs. Dried specimens should be transported to State Laboratory of Hygiene within 24 hours of specimen collection (the State Laboratory of Hygiene provides a next-day courier delivery service). |
| Courier Information: | Purple Mountain Solutions is the selected courier service for the WI newborn screening Laboratory. Purple Mountain Solutions picks up specimens Monday through Saturday and delivers Monday through Saturday. For sample shipping instructions, visit: https://slh.wisc.edu/clinical/newborn/health-care-professionals-guide/how-to-collect-a-blood-specimen/specimen-handling-and-mailing/. |
| Specimen Receiving Hours: | Monday-Friday 7:00 AM - 4:30 PM, Saturday 7:00 AM - 12:00 PM |
| Results Include: | Risk assessment for disorders included on the panel and a recommendation for follow-up action, if necessary. |
| Limitations: | Test results may be compromised if: Specimen is collected prior to 24 hours after birth; Specimen is collected after baby has received a blood transfusion; Specimen is collected while baby is receiving total parenteral nutrition. |
| Additional Tests Recommended: | Confirmatory testing or a repeat newborn screen may be recommended, depending on test results. |
| Additional Comments: |
| Methodology: | Enzymatic assay, immunoreaction assay, electrophoresis, high performance liquid chromatography, tandem mass spectrometry, polymerase chain reaction (PCR), real-time PCR, droplet digital PCR, and sequencing technology |
| Includes: | For information on diseases included in the panel, please visit our website. |
| Regulatory Compliance: | This panel includes assays that are defined as laboratory-developed tests, FDA-approved tests, and modified FDA-approved tests. |
| CPT Code: | S3620 |
| Price: | $195.00 effective 7/11/23 |
| Fee Exempt Eligible: | No |
| Billing and Revenue Office: | 1-800-862-1065 arbill@slh.wisc.edu |