Mycobacterium tuberculosis Susceptibility First Line Drugs
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| WSLH Department: | CDD - Communicable Disease Division |
| WSLH Test Code: | MM00204 |
| Availability: | Monday - Friday |
| Turn-around Time: | 23-6 weeks |
| Recommended Uses: | To determine the in vitro susceptibility of M. tuberculosis complex organisms to first line antimicrobial agents. |
| Contraindications: | |
| Additional Tests Performed: |
| Patient Preparations: | |
| Specimen Requirements: | M. tuberculosis complex isolate in broth or solid media |
| Specimen Handling & Transport: | Mycobacterium tuberculosis isolates should be packaged and transported according to the guidelines outlined for "Category A Infectious Substances." Cultures may be transported to the laboratory at ambient temperatures. Avoid temperature extremes during transport. |
| Collection Kit/Container: | |
| Collection Instructions: | |
| Unacceptable Conditions: | |
| Requisition Form: |
CDD Requisition Form A
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| Required Information: | Identification of organism as a member of the M. tuberculosis complex. Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier; date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), clinician name and UPIN, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label. |
| Results Include: | M. tuberculosis complex organisms Susceptible or Resistant to the listed antimicrobial agents using criteria established by the Clinical and Laboratory Standards Institute (CLSI). |
| Limitations: | **Test can only be performed on pure M. tuberculosis complex isolates. Mixed or contaminated cultures will extend turnaround time significantly and may prevent susceptibility testing. |
| Additional Tests Recommended: | |
| Additional Comments: | **Isolates resistant to rifampin or two first-line drugs are automatically referred to CDC for second-line drug susceptibility testing. **The initial M. tuberculosis complex isolate is genotyped as part of the CDC universal genotyping program. **GeneXpert MTB/RIF will automatically be performed on all isolates submitted for 1st-line DST. |
| Methodology: | MGIT broth method. This test has been approved by the U.S. Food and Drug Administration (FDA). |
| Includes: | Susceptibility tests of M. tuberculosis complex organisms with two concentrations of Isoniazid (I), one concentration of Ethambutol (E), Rifampin (R) and Pyrazinamide (PZA). |
| CPT Code: | 87188x5 |
| Price: | $256.00 |