Mycobacterium tuberculosis Susceptibility First Line Drugs Print

WSLH Department: CDD - Communicable Disease Division
WSLH Test Code: MM00204
Availability: Monday - Friday
Turn-around Time: 23-6 weeks
Recommended Uses: To determine the in vitro susceptibility of M. tuberculosis complex organisms to first line antimicrobial agents.
Additional Tests Performed:
Patient Preparations:
Specimen Requirements: M. tuberculosis complex isolate in broth or solid media
Specimen Handling & Transport: Mycobacterium tuberculosis isolates should be packaged and transported according to the guidelines outlined for "Category A Infectious Substances." Cultures may be transported to the laboratory at ambient temperatures. Avoid temperature extremes during transport.
Collection Kit/Container:
Collection Instructions:
Unacceptable Conditions:
Requisition Form: CDD Requisition Form A
Required Information: Identification of organism as a member of the M. tuberculosis complex. Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier; date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), clinician name and UPIN, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label.
Results Include: M. tuberculosis complex organisms Susceptible or Resistant to the listed antimicrobial agents using criteria established by the Clinical and Laboratory Standards Institute (CLSI).
Limitations: **Test can only be performed on pure M. tuberculosis complex isolates. Mixed or contaminated cultures will extend turnaround time significantly and may prevent susceptibility testing.
Additional Tests Recommended:
Additional Comments: **Isolates resistant to rifampin or two first-line drugs are automatically referred to CDC for second-line drug susceptibility testing. **The initial M. tuberculosis complex isolate is genotyped as part of the CDC universal genotyping program. **GeneXpert MTB/RIF will automatically be performed on all isolates submitted for 1st-line DST.
Methodology: MGIT broth method. This test has been approved by the U.S. Food and Drug Administration (FDA).
Includes: Susceptibility tests of M. tuberculosis complex organisms with two concentrations of Isoniazid (I), one concentration of Ethambutol (E), Rifampin (R) and Pyrazinamide (PZA).
CPT Code: 87188x5
Price: $256.00
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