Measles IgM and IgG Antibody Print

WSLH Department: CDD - Communicable Disease Division
WSLH Test Code: SS02120
Availability: Daily, Monday - Friday
Turn-around Time: 1-2 days
Recommended Uses: Early diagnosis of measles infection in symptomatic patients.
Additional Tests Performed:
Patient Preparations: Acute serum collected 1-7 days after appearance of rash.
Specimen Requirements: Minimum of 0.5 ml serum
Specimen Handling & Transport: Less then 24 hours post-collection: Store serum specimen at 2-8 degrees C and transport with frozen cool packs.

Greater than 24 hours post-collection: Freeze serum (-20 degrees C) and transport on dry ice.
Collection Kit/Container: Serology Specimens
Sterile Transfer Tube
Collection Instructions:
Unacceptable Conditions: Obvious microbial contaminated and lipemic specimens
Requisition Form: CDD Requisition Form B
Required Information: Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier; date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), clinician name and UPIN, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label.
Results Include: Negative, Positive, or Equivocal with interpretation
Limitations: IgM may be negative if specimen collected prior to appearance of the rash. The absence of IgM and IgG does not rule out measles infection, but may indicate that the patient is susceptible to infection. The presence of measles IgM is indicative of a recent exposure, but cannot differentiate between primary infection and vaccination.
Additional Tests Recommended: Measles Virus PCR; Parvovirus IgM for differential diagnosis of rash illness; convalescent serum for measles antibody, diagnostic confirmatory testing.
Additional Comments: IgM antibody is often positive on the day of rash onset. However, in the first 72 hours after rash onset, up to 20% of tests for IgM may give false-negtive results. Tests that are negative in the first 72 hours after rash onset should be repeated.
Methodology: Indirect Fluorescent Antibody (IgM) and Enzyme-Linked Immunosorbent Assay (IgG)
Includes: Quantitative IFA assay for the detection of IgM antibodies and qualitative ELISA assay for the detection of IgG antibodies to Measles (Rubeola) virus
CPT Code: 86765x2
Price: $138.00
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