Measles IgM and IgG Antibody
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| WSLH Department: | CDD - Communicable Disease Division |
| WSLH Test Code: | SS02120 |
| Day(s) Performed: | Daily, Monday - Friday |
| Turn-around Time: | 1-2 days |
| Recommended Uses: | Early diagnosis of measles infection in symptomatic patients. |
| Pre-approval: | N |
| Contraindications: | |
| Additional Tests Performed: |
| Preparation for Collection: | Acute serum collected 1-7 days after appearance of rash. |
| Specimen Requirements: | Minimum of 0.5 ml serum |
| Collection Instructions: | Routine blood draw |
| Collection Kit/Container: |
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| Requisition Form: |
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| Required Information: | Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier, date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), clinician name and UPIN, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label. |
| Rejection Criteria: | Obvious microbial contaminated and lipemic specimens |
| Specimen Handling: | Ship promptly. Store serum specimen at 2-8 °C and transport with frozen cold packs. If the specimen will arrive >3 days from collection, freeze serum (-20 to -80 °C) and transport on dry ice. |
| Packaging Requirements: | |
| Courier Information: | This test is not eligible for fee-exempt courier service unless pre-approved by DHS. |
| Specimen Receiving Hours: | Monday-Friday 7:45 AM - 4:30 PM, Saturday 7:45 AM - 12:00 PM |
| Results Include: | Negative, Positive, or Equivocal with interpretation |
| Limitations: | IgM may be negative if specimen is collected prior to the appearance of a rash. The absence of IgM and IgG does not rule out measles infection, but may indicate that the patient is susceptible to infection. The presence of measles IgM is indicative of a recent exposure, but cannot differentiate between primary infection and vaccination. |
| Additional Tests Recommended: | |
| Additional Comments: | IgM antibody is often positive on the day of rash onset. However, in the first 72 hours after rash onset, up to 20% of tests for IgM may give false-negative results. Tests that are negative in the first 72 hours after rash onset should be repeated. |
| Methodology: | Indirect Fluorescent Antibody (IgM) and Enzyme-Linked Immunosorbent Assay (IgG) |
| Includes: | Quantitative IFA assay for the detection of IgM antibodies and qualitative ELISA assay for the detection of IgG antibodies to Measles (Rubeola) virus |
| Regulatory Compliance: |
| CPT Code: | 86765x2 |
| Price: | $146.00 |
| Fee Exempt Eligible: | Yes, with DHS approval only, 608-267-9003 |
| Billing and Revenue Office: | 1-800-862-1065 arbill@slh.wisc.edu |