Arbovirus IgM Antibody Panel
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| WSLH Department: | CDD - Communicable Disease Division |
| WSLH Test Code: | SS02201 |
| Day(s) Performed: | Test performed weekly |
| Turn-around Time: | 3-14 days |
| Recommended Uses: | Serodiagnosis of a recent infection with any of these agents in individuals with symptoms of arbovirus encephalitis with no other laboratory diagnosis. |
| Contraindications: | Testing will not be performed as a screening test or on patients without symptoms of arbovirus infection. |
| Additional Tests Performed: |
| Patient Preparations: | |
| Specimen Requirements: | 1-3 ml serum or 8.5 ml SST vacutainer tube, no additives; CSF, minimum 2 ml. CSF must be accompanied by serum specimen |
| Specimen Handling & Transport: | Specimens should be stored at 2-8 degrees C, transported with a frozen cool pack, and should be received within 48 hours of collection. If specimens will not be tested for 3 or more days, they should be frozen at -20°C until ready for shipment and shipped on dry ice. |
| Collection Kit/Container: |
Serology Specimens
Sterile Transfer Tube |
| Collection Instructions: | Specimens should be collected in the acute phase of illness. |
| Unacceptable Conditions: | Specimens received without cold packs or dry ice. Specimens collected post mortem are unacceptable for testing |
| Requisition Form: |
CDD Requisition Form B
|
| Required Information: | Clinical information regarding symptoms and onset must be provided. Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier; date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), clinician name and UPIN, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label. |
| Results Include: | Negative, Presumptive Positive or Nonspecific for MIA assay. Numeric value and interpretation as Negative, Equivocal, Presumptive Positive or Non-Specific for IgM capture ELISA. |
| Limitations: | Cross-reaction may occur between the arboviruses. Negative results on a single acute phase specimen do not rule out infection, as specimen may have been obtained prior to the development of an antibody response. |
| Additional Tests Recommended: | |
| Additional Comments: | Both MIA and CEIA test methodologies were developed at the CDC and validated at WSLH. They have not been cleared or approved by the U.S. Food and Drug Administration. Specimens that test Presumptive Positive or Equivocal will be sent to the CDC for additional testing. |
| Methodology: | Qualitative IgM capture ELISA for JCV, POWV and LAC; Microsphere immunoassay (MIA) for WNV/SLE and EEE |
| Includes: | Qualitative IgM testing for Eastern Equine Encephalitis, St. Louis Encephalitis, La Crosse Encephalitis, West Nile Virus, Powassan Virus and Jamestown Canyon Virus. |
| CPT Code: | 86790x2, 86651, 86652, 86653, 86788 |
| Price: | $657.00 |